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US Open 2025 betting guide: why Jannik Sinner leads the odds on Bet365

US Open 2025 betting preview – Bet365 makes Jannik Sinner the outright favourite in Flushing Meadows. Explore odds, rivals, prop bets, and expert betting tips for smart wagering.

Arkya Mitra
Last updated: 22.08.2025
Jannik Sinner leads the odds in US Open 2025

The 2025 US Open has landed in Flushing Meadows, and the bookies are already recalculating their odds - Jannik Sinner is the one to beat. Whether you are browsing the markets on Bet365 or scanning the future across the sportsbooks, the world No. 1 and defending champion is the headliner in the outright markets as punters consider form, fitness and draw.


Why Sinner is the favourite on Bet365

Jannik Sinner enters the 2025 US Open in perhaps the best form of his career in being the undisputed world No. 1 with a series of dominant performances on hard courts this year. The Italian has augmented his characteristic aggressive game of the baseline with better composure in long rallies, making him a virtually perfect player on fast courts. His serve is now one of his greatest weapons as it has been providing free points when needed most, and his return game can still confound even the biggest hitters on the tour. Sinner has had a breakthrough year that has been characterised by consistency at the very top, with multiple ATP titles and deep major runs. This consistency has justified why bookmakers featured on Sportytrader, with Bet365 at the forefront, put him as the undisputed favourite to win the trophy once again at Flushing Meadows.


Context: form, fitness and recent headlines

It is good and bad news that there are reasons to be bullish and cautious about supporting Sinner. He is the top seed and has the draw advantage that goes with that position, but recent illness forced him to retire in the Cincinnati final, and some punters have late fitness concerns. However, it is reported that he should be fit to defend his title when the main draw starts. It is a typical risk/reward calculation on the part of bettors: low odds but high probability versus higher returns on value outsiders.


The impact of Bet365 on markets (and where the value lies)

The US Open coverage offered by Bet365 features outright winner odds, match lines, in-play odds and a large variety of player props, including set handicaps, total games and first-set winners. Many bettors do not get value in the top-line favourite, but in specific markets like:

  • Match props (Sinner to win in straight sets vs. to lose a set)

  • Round-by-round outrights (Sinner to reach semi-finals vs. outright winner)

  • Player props (aces, break points saved, total sets played)

These markets fluctuate as the tournament progresses, so by comparing the Bet365 market to other books, it may highlight slight advantages, especially in the event of injury or weather affecting the draw.


Main competitors and betting marketplace

The most likely rivals to the throne of Sinner in the betting market are Carlos Alcaraz and Novak Djokovic. The only challenger that can be considered in the outright market with any kind of seriousness is Alcaraz, who has had decent performances and a long-standing rivalry with Sinner. Djokovic, despite his age, remains a force to be reckoned with in majors since he has experience and can fight back.


Others (Jack Draper, Ben Shelton, and Alexander Zverev) are priced as possible dark horses, not favourites, and can yield bigger returns to those who bet on them making a breakthrough run. Markets change fast when match-ups and fitness reports are updated, and keeping updated is the key.


Betting advice to punters

1. Look at the draw and injury news before betting on a match, as the seedings and match-ups can play a significant role in Grand Slams.

2. Think round-by-round: betting on Sinner to make the semi-finals or the final can be more rewarding than betting on him to win the tournament.

3. Take a look at player-prop lines: aces, total sets, and service games won may also present opportunities in addition to outright bets.

4. Book prices in various books: even minor variations in odds can be compounded tremendously in futures betting.

5. Play sensibly: establish a stake strategy and do not chase losses. Grand Slam tournaments are long and unpredictable.


Final word

In case you want to bet on the safe favourite, Bet365 has Jannik Sinner as the favourite to win the US Open 2025: the ranking, recent form, and betting algorithms all point to this player. To those seeking higher returns, the most interesting bets will be on well-chosen props and round-by-round outrights, which reflect the unpredictability of the conditions and player match-ups in New York.


Regardless of your betting strategy, it is important to monitor fitness reports and live market action. In a Grand Slam, timing your bet can be equal to the player you bet on.

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