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Top 5 Best FPL Defenders This week: GW6, Premier League 2025-26

Here is our pick of the Best Fantasy Premier League defenders for this week, featuring top FPL options from clubs such as Chelsea, Liverpool, Tottenham Hotspur, and Manchester City.

MF
Last updated: 24.09.2025
Best FPL Defenders GW6, Premier League 2025-26

Are you in search of the best FPL defenders this week? Then look no further as we are here with our pick of the best fantasy premier league defenders for Gameweek 6. GW6 features some really attractive fixtures that are perfect for certain defenders to score huge points. Let's not waste more time then, scroll down to find the best defenders to pick this week in FPL.


Best Fantasy Premier League Defenders - Gameweek 6

Joško Gvardiol (Manchester City, £5.8m)

Manchester City will be facing Burnley at home in Gameweek 6, and that automatically makes any Manchester City player one of the best FPL defenders for this week. Our top Man City Fantasy Premier League defender pick for GW6 is Joško Gvardiol, who would not only guarantee you a clean sheet but potentially further points as well due to his unique attacking threat. However, be aware that Pep Guardiola is notorious when it comes to rotating his players.


Trevoh Chalobah (Chelsea, £5.1m)

Trevoh Chalobah has continued to silence all his doubters and haters at Chelsea. From being unwanted last year by the club to now their starting defender, his story is simply inspirational. With Chelsea facing Brighton who've been struggling a bit this season, Chalobah looks like one of the best Fantasy Premier League defender picks this week.


Marcos Senesi (Bournemouth, £4.7m)

Marcos Senesi is one of the best cheap FPL defenders you can pick for Gameweek 6. Bournemouth have been one of the best sides this season both in terms of attack and defense. They will be heavy favourites against Leeds United, and it would not even be the biggest shock if Senesi himself gets a goal or assist. A stunning risk-free and high reward defender pick for GW6 in our opinion at a cheap £4.5m price range.


Micky van de Ven (Tottenham Hotspur, £4.7m)

Micky van de Ven is another name that's undoubtedly one of the best Fantasy Premier League defenders to pick this week. He is yet another cheap £4.5m price range defender that could end up being a bargain for Gameweek 6. Tottenham will be facing Wolves at home, who have been one of the worst Premier League sides of the season so far. Van de Ven is also in terrific form as well, and we feel that picking him for GW6 is a no-brainer at this point.


Virgil Van Dijk (Liverpool, £6.1m)

Virgil Van Dijk is one of the best premium FPL defender picks for this week. Liverpool will face Oliver Glasner's Crystal Palace side away, which means that the fixture is undoubtedly a tough one. However, we feel that Liverpool will end up winning the game considering the quality they have. Defenders from both sides will be busy, and we are almost certain Van Dijk will score defensive contribution points at the bare minimum. If it all goes well, you might even get another 5-6 points from him if Liverpool get a clean sheet and through bonus points.


These are our Best FPL defenders for this week.  All these players have a high probability of scoring huge points so choose wisely according to your preferences, team structure, and long-term plans.


That's it from our side, see you soon for our best Fantasy Premier League defenders list for Gameweek 7.

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