We are here with our final list of the Best FPL differential Picks this week in Gameweek 38 for the season-end fixtures. Gameweek 38 is often the perfect time for Fantasy Premier League managers to take risks and back low-owned players capable of delivering huge returns. With many mini-leagues still undecided, differential picks can provide the edge needed to climb rankings on the final day of the 2025–26 season. Teams chasing European football, fighting relegation, or simply ending the campaign strongly often produce unexpected fantasy heroes in the closing round. Final-day fixtures also tend to be open and attack-minded, creating ideal conditions for bold punts to succeed and separate managers from the highly-owned template selections.
Best FPL differentials for Gameweek 38 (GW38)
Defenders
Nordi Mukiele (Sunderland, £4.6m)
Sunderland at home are a force to be reckoned with, and Chelsea will thus have to do a lot of hard work to beat them in the final Gameweek. Nordi Mukiele has arguably been their best defender this season, and at a bargain price of just £4.6m, he's certainly one of the best cheap FPL differentials for this week.
Adrien Truffert (Bournemouth, £4.7m)
Adrien Truffert has had an excellent debut season in the Premier League. When Milos Kerkez was sold by Bournemouth, their fans were worried about how the club could replace their star defender. They have gotten their answer in the form of Truffert, who's been sensational for them. With Bournemouth facing Nottingham Forest, Truffert is a great FPL pick this week.
Midfield
Dango Ouattara (Brentford, £5.6m)
Dango Ouattara is in great form at the moment, evident by the fact that he scored a brace against Crystal Palace last week to help his side earn a point. Brentford will next face a Liverpool side that conceded 4 goals against Aston Villa last week. That makes Ouattara a really attractive FPL differential pick for this week.
Rayan Cherki (Manchester City, £6.6m)
Rayan Cherki has been one of the Standout signings of the Premier League this season. He's been brilliant for Pep Guardiola's Man City so far, with his 12 Premier League assists the biggest proof of that. Guardiola has surprisingly rested him a lot in recent games despite his great form, and thus we feel he'll start against Villa. A great FPL differential indeed.
Striker
William Osula (Newcastle, £5.5m)
Newcastle spent more than a 100 million combined to replace striker Alexander Isak with the signings of Yoane Wissa and Nick Woltemade. Not only have both strikers failed to meet the desired expectations so far, but they've both been replaced by a 23 year old William Osula as Newcastle's main risk. He is a high-risk high-reward gamble worth taking in Gameweek 38.
Conclusion
As the season reaches its final chapter, differential picks become even more valuable for managers looking to make late gains in overall rank or mini-league standings. Gameweek 38 is usually full of surprises, dramatic moments, and high-scoring matches, rewarding those willing to trust form, fixtures, and instinct over safe template choices. Smart one-week punts can completely change the outcome of an FPL season, especially when ownership levels are low and motivation remains high. Monitoring injuries, predicted lineups, and teams with something meaningful left to play could be crucial before making those final differential picks in your FPL.
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