Welcome Premier League fans, we are here with Gameweek 22 edition of best FPL differentials this week. The fixtures in GW22 of the EPL are quite interesting, and some of them are especially ideal for certain players who are quite underrated in Fantasy Premier League to end up scoring big. Let's not waste much more time then, scroll down below to find out our best FPL Fpl differentials picks for this week
Best Fantasy premier league differentials this week - Gameweek 22 (GW22)
Defenders
Jeremie Frimpong (Liverpool, £5.7m)
Jeremie Frimpong's Liverpool career didn't not start on a good note, with numerous injury issues preventing him from making any impact at all. However, things seem to have changed now, and Frimpong has been Impressive for Arne Slot's Liverpool side since returning from injury. Frimpong is extremely attacking despite being a defender, and in fact has 2 assists in his last 4 EPL starts. With Burnley at home next for Liverpool, Frimpong is definitely one of the best FPL differentials for this week.
Trai Hume (Sunderland, £4.5m)
Trai Hume has had a fantastic season with Sunderland so far, having been rock solid at the back. The Northern Irish full-back is still just 23 years old, and has the potential to develop into one of the best in the Premier League at his position. Sunderland's next game will be against Oliver Glasner's Crystal Palace, who have been on a disastrous run of form recently. This makes Hume one of the best cheap differential picks for this week with great scope for points.
Midfielders
Bruno Fernandes (Manchester United, £9.1m)
Ruben Amorim getting sacked by Manchester United means that the Red Devils will now be going back to a back 4 system. This means new interim manager Michael Carrrick will revert Bruno Fernandes to the number 10 position, which will give him more attacking freedom and no defensive responsibilities as compared to his No.6 role under the Amorim system. Thus he is an excellent high-risk high-reward type differential for this week in Fantasy Premier League.
Enzo Fernandez (Chelsea, £6.4m)
Enzo Fernandez has been really impressive in the Premier League this season despite Chelsea as a team being quite underwhelming. The Argentine midfielder has already scored 6 league goals this season, which is the same he scored for the entire season last time. New Chelsea manager Liam Rosenior could now help Fernandez develop his game even further. Brentford at home this week is a decent fixture as well, and thus we've included Fernandez in our best FPL differentials predictions list for this week.
Forward
Danny Welbeck (Brighton, £6.2m)
Danny Welbeck is a name that deserves more spotlight and applause for what he has done in the 2025-26 Premier League season so far. The former Manchester United and Arsenal striker has scored 8 Premier League for Brighton in just 20 games, that too at the age of 35. He is proving to everyone that age is just a number at this moment. Brighton will face Bournemouth at home in Gameweek 22, who were already in poor form and have now lost their best player Antoine Semenyo to Manchester City. Thus, Welbeck definitely stands out as one of the best FPL differentials for this week.
These were our best Fantasy premier league differential predictions for this week (Gameweek 22). All our selection differential picks above have a huge scope of ending the Gameweek with high points, so pick them according to your preferences. Your selection of differentials is what'll make your Fantasy Premier League team stand out from the rest, so always try to make the right choice after careful consideration. That's it from our side then, see you soon for Best FPL differentials for Gameweek 23.
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